Related Parties - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands		1 Months Ended			3 Months Ended		9 Months Ended
	Jul. 13, 2020	Jan. 31, 2022	Feb. 28, 2021	May 31, 2020	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021	Dec. 31, 2021
Related Party Transaction [Line Items]
Receivable from collaboration partners, current					$ 27,286		$ 27,286		$ 744,595
Related party, deferred revenue - current					103,291		103,291		96,981
Related party, deferred revenue - noncurrent					382,584		382,584		$ 462,217
Gilead Collaboration Agreement
Related Party Transaction [Line Items]
Revenue recognized					$ 32,100	$ 7,700	$ 73,300	$ 23,100
Gilead
Related Party Transaction [Line Items]
Percentage of outstanding common stock held					19.10%		19.10%
Number of shares issued				2,200,000
Value of common stock issued				$ 56,700
Option payments received		$ 725,000
Gilead | Operating Expenses
Related Party Transaction [Line Items]
Reimbursed under cost-sharing provisions of arrangement					$ 27,100	800	$ 93,400	6,900
Gilead | Cost Sharing Receivable
Related Party Transaction [Line Items]
Receivable from collaboration partners, current					26,500		26,500
Related party, deferred revenue - current					103,300		103,300
Related party, deferred revenue - noncurrent					382,600		382,600
Gilead | Cost Sharing Receivable | Other Noncurrent Assets
Related Party Transaction [Line Items]
Receivable from collaboration partners, noncurrent					$ 1,900		$ 1,900
Gilead | Maximum
Related Party Transaction [Line Items]
Right to purchase additional outstanding voting common stock percentage					35.00%		35.00%
Gilead | Gilead Collaboration Agreement
Related Party Transaction [Line Items]
Revenue recognized					$ 32,100	$ 7,700	$ 73,300	$ 23,100
Upfront cash payment							175,000
Gilead | Stock Purchase Agreement
Related Party Transaction [Line Items]
Issuance of common stock, shares	5,963,029		5,650,000
Issuance of common stock			$ 220,400				327,800
Funds received for purchase of common stock							200,000
Fair value of stock purchased							109,400
Premium on stock purchased							$ 90,600
Shares issued, price per share			$ 39.00