Net Loss per Share (Tables)

6 Months Ended

Jun. 30, 2022

Earnings Per Share [Abstract]

Computation of Basic and Diluted Net Loss Per Share

The following table sets forth the computation of basic and diluted net loss per share (in thousands, except share and per share data):

	Three Months Ended June 30,						Six Months Ended June 30,
	2022			2021			2022			2021
Numerator:
Net loss	$	(66,632	)	$	(75,970	)	$	(134,625	)	$	(148,563	)
Denominator:
Weighted-average common shares outstanding		71,814,232			71,094,199			71,506,216			69,792,730
Less: weighted-average common shares subject to vesting		-			(1,348,902	)		-			(1,371,644	)
Weighted-average common shares used to compute basic and diluted net loss per share		71,814,232			69,745,297			71,506,216			68,421,086
Net loss per share: basic and diluted	$	(0.93	)	$	(1.09	)	$	(1.88	)	$	(2.17	)

Summary of Outstanding Potentially Dilutive Securities Excluded from Computation of Diluted Net Loss per Share

The following outstanding potentially dilutive securities were excluded from the computation of diluted net loss per share because including them would have been antidilutive:

	As of June 30,
	2022		2021
Common stock options issued and outstanding		12,404,112		12,508,782
Restricted stock units issued		1,397,281		1,330,120
Employee Stock Purchase Plan shares		135,040		169,326
Unvested early exercised common stock options		-		73,618
Unvested restricted common stock issued as   part of collaboration agreement		-		1,257,651
Total		13,936,433		15,339,497