Related Parties - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands		1 Months Ended			3 Months Ended
	Jul. 13, 2020	Jan. 31, 2022	Feb. 28, 2021	May 31, 2020	Mar. 31, 2022	Mar. 31, 2021	Dec. 31, 2021
Related Party Transaction [Line Items]
Receivable from collaboration partners, current					$ 29,419		$ 744,595
Related party, deferred revenue - current					86,038		96,981
Related party, deferred revenue - noncurrent					$ 456,905		$ 462,217
Gilead
Related Party Transaction [Line Items]
Percentage of outstanding common stock held					19.30%
Number of shares issued				2,200,000
Value of common stock issued				$ 56,700
Option payments received		$ 725,000
Gilead | Operating Expenses
Related Party Transaction [Line Items]
Reimbursed under cost-sharing provisions of arrangement					$ 30,400	$ 4,900
Gilead | Cost Sharing Receivable
Related Party Transaction [Line Items]
Receivable from collaboration partners, current					29,300
Related party, deferred revenue - current					86,000
Related party, deferred revenue - noncurrent					456,900
Gilead | Cost Sharing Receivable | Other Noncurrent Assets
Related Party Transaction [Line Items]
Receivable from collaboration partners, noncurrent					$ 1,100
Gilead | Maximum
Related Party Transaction [Line Items]
Right to purchase additional outstanding voting common stock percentage					35.00%
Gilead | Gilead Collaboration Agreement
Related Party Transaction [Line Items]
Revenue recognized					$ 16,300	$ 7,700
Upfront cash payment					175,000
Gilead | Stock Purchase Agreement
Related Party Transaction [Line Items]
Issuance of common stock, shares	5,963,029		5,650,000
Issuance of common stock			$ 220,400		327,800
Funds received for purchase of common stock					200,000
Fair value of stock purchased					109,400
Premium on stock purchased					$ 90,600
Shares issued, price per share			$ 39.00