Liability for Sale of Future Royalties - Additional Information (Details) - BVF Partners L.P. - BVF Agreement - USD ($)	1 Months Ended	3 Months Ended		12 Months Ended
	Oct. 31, 2021	Mar. 31, 2022	Dec. 31, 2021	Dec. 31, 2022
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Payment to be made for discovery and development of compounds	$ 15,000,000
Cash received from counterparty		$ 5,000,000	$ 5,000,000
Option to provide additional funding	10,000,000
Liability for milestone payments and royalties		$ 10,700,000
Imputed effective rate of interest on unamortized portion of liability		20.60%
Non-cash interest expense		$ 400,000
Minimum
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Payment to be made for discovery and development of compounds	15,000,000
Contingent payments upon achievement of certain clinical and regulatory milestones	72,500,000
Maximum
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Contingent payments upon achievement of certain clinical and regulatory milestones	$ 160,000,000.0
Scenario Forecast
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Cash received from counterparty				$ 5,000,000