Liability for Sale of Future Royalties - Additional Information (Details) - BVF Partners L.P. - BVF Agreement - USD ($)	1 Months Ended	3 Months Ended		12 Months Ended
	Oct. 31, 2021	Mar. 31, 2022	Dec. 31, 2021	Dec. 31, 2022	Dec. 31, 2021
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Payment to be made for discovery and development of compounds	$ 15,000,000
Cash received from counterparty			$ 5,000,000
Option to provide additional funding	10,000,000
Liability for milestone payments and royalties			$ 5,300,000		$ 5,300,000
Imputed effective rate of interest on unamortized portion of liability					20.60%
Scenario Forecast
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Cash received from counterparty		$ 5,000,000		$ 5,000,000
Minimum
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Contingent payments upon achievement of certain clinical and regulatory milestones	72,500,000
Cash received from counterparty					$ 15,000,000
Maximum
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Contingent payments upon achievement of certain clinical and regulatory milestones	$ 160,000,000.0