Net Income (Loss) per Share (Tables)

12 Months Ended

Dec. 31, 2021

Earnings Per Share [Abstract]

Computation of Basic and Diluted Net Income (Loss) Per Share

The following table sets forth the computation of basic and diluted net income (loss) per share (in thousands, except share and per share data):

	Year Ended December 31,
	2021			2020			2019
Numerator:
Net income (loss)	$	52,830		$	(122,858	)	$	(84,710	)
Denominator:
Weighted-average common shares outstanding		70,328,234			56,354,059			45,385,489
Less: weighted-average common shares subject to    vesting		(982,744	)		(1,566,941	)		(1,559,498	)
Weighted-average common shares used to compute    basic net income (loss) per share		69,345,490			54,787,118			43,825,991
Dilutive effect of stock options		4,054,142			-			-
Dilutive effect of restricted stock units		566,635			-			-
Weighted-average common shares used to compute    diluted net income (loss) per share		73,966,267			54,787,118			43,825,991
Net income (loss) per share, basic	$	0.76		$	(2.24	)	$	(1.93	)
Net income (loss) per share, diluted	$	0.71		$	(2.24	)	$	(1.93	)

Summary of Outstanding Potentially Dilutive Securities Excluded from Computation of Diluted Net Income (Loss) per Share

The following outstanding potentially dilutive securities were excluded from the computation of diluted net income (loss) per share for the periods presented because including them would have been antidilutive:

	At December 31,
	2021		2020		2019
Common stock options issued and outstanding		4,512,973		9,892,697		4,738,004
Restricted stock units issued		-		738,650		-
Unvested early exercised common stock options		-		165,133		455,158
Employee Stock Purchase Plan shares		103,046		18,219		-
Unvested restricted stock issued as part of collaboration agreement		-		1,257,651		1,257,651
Total		4,616,019		12,072,350		6,450,813