X0206 3 2018-09-25 0 0001724344 Entasis Therapeutics Holdings Inc. ETTX 0001687333 Gutch Michael C/O ENTASIS THERAPEUTICS HOLDINGS INC. 35 GATEHOUSE DRIVE WALTHAM MA 02451 0 1 0 0 CFO and Chief Business Officer Employee Stock Option (Right to Buy) 3.74 2027-06-01 Common Stock 41069 D Employee Stock Option (Right to Buy) 3.11 2027-11-21 Common Stock 25092 D Employee Stock Option (Right to Buy) 6.85 2028-04-30 Common Stock 30006 D Twenty-five percent (25%) of the shares subject to the option vested on April 1, 2018, and one thirty-sixth (1/36th) of the remaining shares subject to the option shall vest each month thereafter on the last day of the month, subject to Reporting Person continuing to provide service through each such date. Twenty-five percent (25%) of the shares subject to the option vested on August 25, 2018, and one thirty-sixth (1/36th) of the remaining shares subject to the option shall vest each month thereafter on the last day of the month, subject to Reporting Person continuing to provide service through each such date. Twenty-five percent (25%) of the shares subject to the option shall vest on December 6, 2018, and one thirty-sixth (1/36th) of the remaining shares subject to the option shall vest each month thereafter on the last day of the month, subject to Reporting Person continuing to provide service through each such date. Exhibit List - Exhibit 24 - Power of Attorney /s/ Christian Plaza, Attorney-in-Fact 2018-09-25