X0306 4 2019-06-19 0 0001724344 Entasis Therapeutics Holdings Inc. ETTX 0001405104 Norden Gregory C/O ENTASIS THERAPEUTICS HOLDINGS INC., 35 GATEHOUSE DRIVE WALTHAM MA 02451 1 0 0 0 Stock Option (Right to Buy) 6.12 2019-06-19 4 A 0 7500 0 A 2029-06-18 Common Stock 7500 7500 D The shares subject to this option will vest in equal monthly installments over the 12 months following the date of grant, provided that the option will in any case be fully vested on the date of the next annual stockholder meeting, subject to the Reporting Persons's continued service through each such vesting date. Exhibit List - See Exhibit 24 - Power of Attorney Elizabeth M. Keiley as Attorney-in-Fact for Gregory Norden 2019-06-21