X0306 4 2019-10-23 0 0001714899 Denali Therapeutics Inc. DNLI 0001724311 Schuth Alexander O. C/O DENALI THERAPEUTICS INC. 161 OYSTER POINT BLVD. SOUTH SAN FRANCISCO CA 94080 0 1 0 0 COO and Secretary Common Stock 599378 I See footnote Common Stock 10711 I See footnote Common Stock 2019-10-23 4 M 0 5129 5.28 A 25839 D Stock Option (right to buy) 5.28 2019-10-23 4 M 0 5129 0.00 D 2027-03-07 Common Stock 5129 112769 D On September 20, 2019 the Reporting Person transferred a total of 10,711 shares of Common Stock for no value received from the Schuth Family Trust to the Alexander Olaf Schuth Trust. The shares are held of record by the Schuth Family Trust, for which the Reporting Person serves as trustee. The shares are held of record by the Alexander Olaf Schuth Trust, for which the Reporting Person serves as trustee. 25% of the shares subject to the option vested on March 8, 2018 and an additional 1/48 of the shares vest monthly thereafter. /s/ Tyler Nielsen, by power of attorney 2019-10-25