SHARE-BASED COMPENSATION - Stock-based compensation expense - Options (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Former Chief Executive Officer
Share-Based Compensation Awards
Stock-based compensation expenses			$ 9,286
Stock options
Share-Based Compensation Awards
Stock-based compensation expenses	$ 3,257	$ 4,829	21,822	$ 14,209
Stock options | Research and development expense
Share-Based Compensation Awards
Stock-based compensation expenses	1,801	1,827	5,582	5,271
Stock options | Selling, general, and administrative
Share-Based Compensation Awards
Stock-based compensation expenses	$ 1,456	$ 3,002	$ 16,240	$ 8,938