License Agreements (Details) $ in Thousands	1 Months Ended	3 Months Ended		9 Months Ended
	Oct. 31, 2017 USD ($)	Sep. 30, 2022 USD ($) item	Sep. 30, 2021 USD ($)	Sep. 30, 2022 USD ($) item	Sep. 30, 2021 USD ($)
License Agreements
Research and development		$ 13,937	$ 17,399	$ 48,643	$ 45,776
MEE License
License Agreements
Number of domestic patients | item		3,000		3,000
IND filing period				18 months
Fair value of stock	$ 100
Period for start commercial sale of product				10 years
Number of days for advance written notice				90 days
Research and development		$ 0	0	$ 0	0
MEE License | Maximum
License Agreements
Milestone payment amount		$ 17,700		$ 17,700
Lonza Sublicense
License Agreements
Number of domestic patients | item		3,000		3,000
IND filing period				18 months
Fair value of stock	$ 100
Period for start commercial sale of product				10 years
Number of days for advance written notice				90 days
Research and development		$ 0	$ 0	$ 0	$ 0
Lonza Sublicense | Maximum
License Agreements
Milestone payment amount		$ 18,500		$ 18,500