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  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001733369</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001720893</issuerCik>
      <issuerName>BioXcel Therapeutics, Inc.</issuerName>
      <secFileNumber>001-38410</secFileNumber>
      <issuerAddress>
        <com:street1>555 LONG WHARF DRIVE</com:street1>
        <com:city>NEW HAVEN</com:city>
        <com:stateOrCountry>CT</com:stateOrCountry>
        <com:zipCode>06511</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>203-643-8060</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Mehta Vimal</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Merrill Lynch</name>
        <address>
          <com:street1>100 Federal St. 12th Floor</com:street1>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>6500</noOfUnitsSold>
      <aggregateMarketValue>167641.02</aggregateMarketValue>
      <noOfUnitsOutstanding>29159638</noOfUnitsOutstanding>
      <approxSaleDate>05/22/2023</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/12/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>BioXcel Therapeutics. Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6500</amountOfSecuritiesAcquired>
      <paymentDate>05/12/2023</paymentDate>
      <natureOfPayment>Company Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Vimal Mehta</name>
        <address>
          <com:street1>555 Long Wharf Dr</com:street1>
          <com:city>New Haven</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06511</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Bioxcel Therapeutics, Inc</securitiesClassTitle>
      <saleDate>03/20/2023</saleDate>
      <amountOfSecuritiesSold>30000</amountOfSecuritiesSold>
      <grossProceeds>549457.29</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Vimal Mehta</name>
        <address>
          <com:street1>555 Long Wharf Dr.</com:street1>
          <com:city>New Haven</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06511</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>BioXcel Therapeutics, Inc.</securitiesClassTitle>
      <saleDate>03/20/2023</saleDate>
      <amountOfSecuritiesSold>4500</amountOfSecuritiesSold>
      <grossProceeds>82368.85</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Vimal Mehta</name>
        <address>
          <com:street1>555 Long Wharf Dr.</com:street1>
          <com:city>New Haven</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06511</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>BioXcel Therapeutics, Inc.</securitiesClassTitle>
      <saleDate>03/21/2023</saleDate>
      <amountOfSecuritiesSold>30000</amountOfSecuritiesSold>
      <grossProceeds>591367.74</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>05/22/2023</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>08/31/2022</planAdoptionDate>
      </planAdoptionDates>
      <signature>Vimal Mehta</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
