<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144/A</submissionType>
    <previousAccessionNumber>0001971857-23-000111</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001847919</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001720893</issuerCik>
      <issuerName>BioXcel Therapeutics, Inc.</issuerName>
      <secFileNumber>001-38410</secFileNumber>
      <issuerAddress>
        <com:street1>555 LONG WHARF DRIVE</com:street1>
        <com:city>NEW HAVEN</com:city>
        <com:stateOrCountry>CT</com:stateOrCountry>
        <com:zipCode>06511</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>203-643-8060</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Rodriguez Javier</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Merrill Lynch</name>
        <address>
          <com:street1>500 Cummings Center</com:street1>
          <com:street2>Suite 1600</com:street2>
          <com:city>Beverly</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>01915</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>1785</noOfUnitsSold>
      <aggregateMarketValue>48691.27</aggregateMarketValue>
      <noOfUnitsOutstanding>29159638</noOfUnitsOutstanding>
      <approxSaleDate>05/15/2023</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>05/12/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Units</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>BioXcel Therapeutics</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>1785</amountOfSecuritiesAcquired>
      <paymentDate>05/15/2023</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Javier Rodriguez</name>
        <address>
          <com:street1>555 Long Wharf Drive</com:street1>
          <com:city>New Haven</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06511</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>03/15/2023</saleDate>
      <amountOfSecuritiesSold>950</amountOfSecuritiesSold>
      <grossProceeds>18615.10</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>144 was submitted yesterday but after submission it was realized that for the Aquisition date the date of grant was included rather than the date that the shares vested. Only change in this amendment is the Aquisition date of the shares. Name of person who acquired was originally listed as individual who sold and has been corrected to BioXcel Therapeutics, the company.</remarks>
    <noticeSignature>
      <noticeDate>05/16/2023</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>06/22/2022</planAdoptionDate>
      </planAdoptionDates>
      <signature>Javier Rodriguez</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
