<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<headerData>
<submissionType>144/A</submissionType>
<previousAccessionNumber>0000950170-24-075613</previousAccessionNumber>
<filerInfo>
<filer>
<filerCredentials>
<cik>0001553352</cik>
<ccc>XXXXXXXX</ccc>
</filerCredentials>
</filer>
<liveTestFlag>LIVE</liveTestFlag>
</filerInfo>
</headerData>
<formData>
<issuerInfo>
<issuerCik>0001719714</issuerCik>
<issuerName>Mereo BioPharma Group plc</issuerName>
<secFileNumber>001-38452</secFileNumber>
<issuerAddress>
<street1 xmlns="http://www.sec.gov/edgar/common">4th Floor, One Cavendish Place</street1>
<city xmlns="http://www.sec.gov/edgar/common">London</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">X0</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">W1G 0QF</zipCode>
</issuerAddress>
<issuerContactPhone>44-333 023 7300</issuerContactPhone>
<nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Lewicki John A.</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
<relationshipsToIssuer>
<relationshipToIssuer>Officer</relationshipToIssuer>
</relationshipsToIssuer>
</issuerInfo>
<securitiesInformation>
<securitiesClassTitle>American Depositary Shares Representing Ordinary Shares</securitiesClassTitle>
<brokerOrMarketmakerDetails>
<name>Morgan Stanley &amp; Co. LLC</name>
<address>
<street1 xmlns="http://www.sec.gov/edgar/common">1585 Broadway</street1>
<city xmlns="http://www.sec.gov/edgar/common">New York</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">NY</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">10036-8293</zipCode>
</address>
</brokerOrMarketmakerDetails>
<noOfUnitsSold>26647</noOfUnitsSold>
<aggregateMarketValue>106055.06</aggregateMarketValue>
<noOfUnitsOutstanding>765150254</noOfUnitsOutstanding>
<approxSaleDate>06/25/2024</approxSaleDate>
<securitiesExchangeName>Nasdaq</securitiesExchangeName>
</securitiesInformation>
<securitiesToBeSold>
<securitiesClassTitle>American Depositary Shares Representing Ordinary Shares</securitiesClassTitle>
<acquiredDate>06/21/2024</acquiredDate>
<natureOfAcquisitionTransaction>Same Day Cashless Exercise and Sale</natureOfAcquisitionTransaction>
<nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
<isGiftTransaction>N</isGiftTransaction>
<amountOfSecuritiesAcquired>69000</amountOfSecuritiesAcquired>
<paymentDate>06/21/2024</paymentDate>
<natureOfPayment>Equity Compensation</natureOfPayment>
</securitiesToBeSold>
<nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
<remarks>This form 144 amends and supersedes the form 144 filed on June 20, 2024. The name and address of the broker has been corrected.</remarks>
<noticeSignature>
<noticeDate>06/24/2024</noticeDate>
<signature>/s/ John A. Lewicki</signature>
</noticeSignature>
</formData>
</edgarSubmission>
