<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2022-02-09</periodOfReport>

    <issuer>
        <issuerCik>0001719489</issuerCik>
        <issuerName>Kaleyra, Inc.</issuerName>
        <issuerTradingSymbol>KLR</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001802748</rptOwnerCik>
            <rptOwnerName>Hirsch Emilio</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O KALEYRA, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>VIA MARCO D'AVIANO, 2, MILANO MI</rptOwnerStreet2>
            <rptOwnerCity>MILAN</rptOwnerCity>
            <rptOwnerState>L6</rptOwnerState>
            <rptOwnerZipCode>20131</rptOwnerZipCode>
            <rptOwnerStateDescription>ITALY</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001814680</rptOwnerCik>
            <rptOwnerName>EFFE PI Societa Semplice</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>41 VIA VALEGGIO</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>TORINO</rptOwnerCity>
            <rptOwnerState>L6</rptOwnerState>
            <rptOwnerZipCode>10129</rptOwnerZipCode>
            <rptOwnerStateDescription>ITALY</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001795992</rptOwnerCik>
            <rptOwnerName>Esse Effe S.p.A.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>41 VIA VALLEGIO</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>TORINO</rptOwnerCity>
            <rptOwnerState>L6</rptOwnerState>
            <rptOwnerZipCode>10129</rptOwnerZipCode>
            <rptOwnerStateDescription>ITALY</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2022-02-09</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>35000</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>113923</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>93104</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By EFFE PI Societa Semplice</value>
                    <footnoteId id="F4"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>5616336</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Esse Effe S.p.A.</value>
                    <footnoteId id="F5"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Subject to the Reporting Person's continued service to the Issuer, the Restricted Stock Units (&quot;RSUs&quot;) vest in sixteen quarterly installments, beginning on May 1, 2022 and ending on February 1, 2026.</footnote>
        <footnote id="F2">Includes additional RSUs subject to vesting pursuant to previously disclosed vesting schedules.</footnote>
        <footnote id="F3">All RSUs shall immediately vest in the event of a Change of Control (as defined in the Issuer's 2019 Equity Incentive Plan) of the Issuer.  In addition, to the extent that the Reporting Person has served as a director for at least three years during any period after November 25, 2019, and such Reporting Person either resigns from the Board or chooses not to stand for reelection as a member of the Board and as a result, separates from service with the Issuer, 100% of the then unvested portion of any RSUs held by such Reporting Person will also immediately become fully vested upon the date of such separation from service.</footnote>
        <footnote id="F4">EFFE PI Societa Semplice (&quot;EFFE PI&quot;) is affiliated with Emilio Hirsch, and Mr. Hirsch is deemed to have acquired a beneficial ownership interest in the reported securities held by EFFE PI.</footnote>
        <footnote id="F5">Esse Effe S.p.A. (&quot;Esse Effe&quot;) is now affiliated with EFFE PI and Emilio Hirsch, and EFFE PI and Mr. Hirsch are each deemed to have acquired a beneficial ownership interest in the reported securities held by Esse Effe.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Emilio Hirsch, Individually</signatureName>
        <signatureDate>2022-02-11</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Emilio Hirsch, Managing Partner of EFFE PI Societa Semplice</signatureName>
        <signatureDate>2022-02-11</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Emilio Hirsch, Director of Esse Effe S.p.A.</signatureName>
        <signatureDate>2022-02-11</signatureDate>
    </ownerSignature>
</ownershipDocument>
