SCHEDULE 13G 0001719307 XXXXXXXX LIVE Common Stock 03/11/2025 0001860782 2seventy bio, Inc. 901384107 60 Binney Street Cambridge MA 02210 Rule 13d-1(b) Rule 13d-1(c) Beryl Capital Management LLC a DE 0.00 4250000.00 0.00 4250000.00 4250000.00 N 8.1 IA OO Percentage calculated based on 52,299,632 shares of Common Stock outstanding on March 10, 2025, as disclosed in the Agreement and Plan of Merger attached as an exhibit to the Form 8-K filed by the Issuer on March 11, 2025. Beryl Capital Management LP a DE 0.00 4250000.00 0.00 4250000.00 4250000.00 N 8.1 IA PN Percentage calculated based on 52,299,632 shares of Common Stock outstanding on March 10, 2025, as disclosed in the Agreement and Plan of Merger attached as an exhibit to the Form 8-K filed by the Issuer on March 11, 2025. Beryl Capital Partners II LP DE 0.00 3438979.00 0.00 3438979.00 3438979.00 N 6.6 PN Percentage calculated based on 52,299,632 shares of Common Stock outstanding on March 10, 2025, as disclosed in the Agreement and Plan of Merger attached as an exhibit to the Form 8-K filed by the Issuer on March 11, 2025. David A. Witkin a X1 0.00 4250000.00 0.00 4250000.00 4250000.00 N 8.1 HC IN Percentage calculated based on 52,299,632 shares of Common Stock outstanding on March 10, 2025, as disclosed in the Agreement and Plan of Merger attached as an exhibit to the Form 8-K filed by the Issuer on March 11, 2025. 2seventy bio, Inc. 60 BINNEY STREET CAMBRIDGE MASSACHUSETTS 02210 Beryl Capital Management LLC, a Delaware limited liability company ("Beryl") Beryl Capital Management LP, a Delaware limited partnership ("Beryl GP") Beryl Capital Partners II LP, a Delaware limited partnership (the "Partnership") David A. Witkin Each reporting person disclaims beneficial ownership of Common Stock except to the extent of that person's pecuniary interest therein. In addition, the filing of this Schedule 13G on behalf of the Partnership should not be construed as an admission that it is, and it disclaims that it is, a beneficial owner, as defined in Rule 13d-3 under the Act, of any Common Stock covered by this Schedule 13G. 225 Avenue I, Suite 205 Redondo Beach, CA 90277 See Item 4 of the cover sheet for each reporting person. N IA HC Beryl: 4,250,000 Beryl GP: 4,250,000 Partnership: 3,438,979 David A Witkin: 4,250,000 Beryl: 8.1% Beryl GP: 8.1% Partnership: 6.6% David A. Witkin: 8.1% Beryl: 0 Beryl GP: 0 Partnership: 0 David A. Witkin: 0 Beryl: 4,250,000 Beryl GP: 4,250,000 Partnership: 3,438,979 David A Witkin: 4,250,000 Beryl: 0 Beryl GP: 0 Partnership: 0 David A. Witkin: 0 Beryl: 4,250,000 Beryl GP: 4,250,000 Partnership: 3,438,979 David A Witkin: 4,250,000 Y Y Y N Beryl is the investment adviser to the Partnership and other accounts. Beryl is the general partner of Beryl GP, which is the general partner of the Partnership and other private investment funds. Mr. Witkin is the control person of Beryl. Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit 99.1 - Agreement Regrding Joint Filing of Statement on Schedule 13D or 13G Beryl Capital Management LLC /s/ Andrew Nelson 03/18/2025 Beryl Capital Management LP /s/ Andrew Nelson 03/18/2025 Beryl Capital Partners II LP /s/ Andrew Nelson 03/18/2025 David A. Witkin /s/ David A. Witkin 03/18/2025