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Document and Entity Information - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Mar. 01, 2022
Jun. 30, 2021
Cover [Abstract]      
Document Type 10-K    
Amendment Flag false    
Document Period End Date Dec. 31, 2021    
Document Fiscal Year Focus 2021    
Document Fiscal Period Focus FY    
Current Fiscal Year End Date --12-31    
Entity Registrant Name PROMETHEUS BIOSCIENCES, INC.    
Entity Central Index Key 0001718852    
Entity Current Reporting Status Yes    
Entity Interactive Data Current Yes    
Entity Voluntary Filers No    
Entity Well-known Seasoned Issuer No    
Entity Small Business true    
Entity Emerging Growth Company true    
Entity Ex Transition Period false    
Entity Shell Company false    
Entity Filer Category Non-accelerated Filer    
Entity Public Float     $ 738.0
Entity Common Stock, Shares Outstanding   39,073,802  
Entity File Number 001-40187    
Entity Incorporation, State or Country Code DE    
Entity Tax Identification Number 81-4282653    
Entity Address, Address Line One 9410 Carroll Park Drive    
Entity Address, City or Town San Diego    
Entity Address, State or Province CA    
Entity Address, Postal Zip Code 92121    
City Area Code 858    
Local Phone Number 684-1300    
ICFR Auditor Attestation Flag false    
Title of 12(b) Security Common Stock, $0.0001 par value per share    
Trading Symbol RXDX    
Security Exchange Name NASDAQ    
Document Annual Report true    
Document Transition Report false    
Auditor Name BDO USA, LLP    
Auditor Location San Diego, CA    
Auditor Firm ID 243    
Documents Incorporated by Reference

DOCUMENTS INCORPORATED BY REFERENCE

Certain sections of the registrant’s definitive proxy statement for the 2022 annual meeting of stockholders to be filed with the Securities and Exchange Commission pursuant to Regulation 14A not later than 120 days after the end of the fiscal year covered by this Form 10-K are incorporated by reference into Part III of this Form 10-K.