Income Taxes (Tables)

12 Months Ended

Dec. 31, 2022

Income Tax Disclosure [Abstract]

Schedule of Income Before Income Taxes

	Year Ended December 31,
	2022		2021		2020
Income (loss) before taxes:
Domestic	$	(63,586)	$	(78,485)	$	59,346
Foreign	—		—		—
Total income (loss) before income taxes	$	(63,586)	$	(78,485)	$	59,346

Schedule of Reconciliation of Effective Income Tax Rate

A reconciliation of the U.S. federal statutory income tax rate to the Company’s effective income tax rate is as follows:

	Year Ended December 31,
	2022		2021		2020
Federal statutory income tax rate	(21.0)	%	(21.0)	%	21.0	%
State taxes, net of federal benefit	(5.6)	%	(12.5)	%	6.3	%
Stock-based compensation	1.5	%	0.2	%	0.5	%
Research and development tax credits	(6.7)	%	(5.0)	%	(3.2)	%
Change in deferred tax asset valuation allowance	31.4	%	38.1	%	(24.5)	%
Other	0.4	%	0.2	%	(0.1)	%
Effective income tax rate	—	%	—	%	—	%

Schedule of Components of Deferred Tax Assets and Liabilities

Significant components of the Company's deferred tax assets and liabilities as of December 31, 2022 and 2021 are as follows:

	December 31,
	2022		2021
Deferred tax assets:
Net operating loss carryforwards	$	30,531	$	30,313
Research and development tax credit carryforwards	16,458		12,230
Intangible assets	1,841		1,812
Accrued expenses	1,065		1,422
Stock-based compensation	5,907		5,237
Lease liability	8,217		8,808
Interest expense	673		269
Capitalized R&D expenditures	14,739		—
Other	248		180
Total deferred tax assets	79,679		60,271
Valuation allowance	(72,203)		(51,957)
Deferred tax assets	7,476		8,314
Deferred tax liabilities:
Right-of-use asset	(6,559)		(7,056)
Depreciation	(895)		(1,150)
Beneficial conversion feature on convertible note payable	(22)		(32)
Other	—		(76)
Total deferred tax liabilities	(7,476)		(8,314)
Net deferred tax assets	$	—	$	—

Summary of Changes in Valuation Allowance for Deferred Tax Assets

The valuation allowance increase primarily relates to the Company's revenue recognition for tax purposes, and were as follows:

	Year Ended December 31,
	2022		2021		2020
Valuation allowance at beginning of year	$	(51,957)	$	(21,961)	$	(36,535)
Increases recorded to income tax provision	(21,194)		(30,616)		(11,675)
Decreases recorded as a benefit to income tax provision	948		620		26,249
Valuation allowance at end of year	$	(72,203)	$	(51,957)	$	(21,961)