Collaboration and License Agreements - Schedule of Collaboration Revenue Related Party (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaboration revenue - related party	$ 0	$ 38,592	$ 15,360
License-related revenue	2,687	87,570	0
Novartis Collaboration
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaboration revenue - related party	0	38,592	15,360
License | GSK Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
License-related revenue	$ 2,687	$ 87,570	$ 0