Income Taxes (Tables)

12 Months Ended

Dec. 31, 2021

Income Tax Disclosure [Abstract]

Schedule of Income Before Income Taxes

	Year Ended December 31,
	2021		2020		2019
Income (loss) before taxes:
Domestic	$	(78,485)	$	59,346	$	(54,789)
Foreign	—		—		—
Total income (loss) before income taxes	$	(78,485)	$	59,346	$	(54,789)

Schedule of Reconciliation of Effective Income Tax Rate

A reconciliation of the U.S. federal statutory income tax rate to the Company’s effective income tax rate is as follows:

	Year Ended December 31,
	2021		2020		2019
Federal statutory income tax rate	(21.0)	%	21.0	%	(21.0)	%
State taxes, net of federal benefit	(12.5)	%	6.3	%	(6.2)	%
Stock-based compensation	0.2	%	0.5	%	1.0	%
Research and development tax credits	(5.0)	%	(3.2)	%	(7.9)	%
Change in deferred tax asset valuation allowance	38.1	%	(24.5)	%	33.7	%
Other	0.2	%	(0.1)	%	0.4	%
Effective income tax rate	—	%	—	%	—	%

Schedule of Components of Deferred Tax Assets and Liabilities

Significant components of the Company's deferred tax assets and liabilities as of December 31, 2021 and 2020 are as follows:

	December 31,
	2021		2020
Deferred tax assets:
Net operating loss carryforwards	$	30,313	$	8,635
Research and development tax credit carryforwards	12,230		8,344
Intangible assets	1,812		1,235
Accrued expenses	1,422		—
Stock-based compensation	5,237		3,911
Lease liability	8,808		9,428
Interest expense	269		—
Other	180		—
Total deferred tax assets	60,271		31,553
Valuation allowance	(51,957)		(21,961)
Deferred tax assets	8,314		9,592
Deferred tax liabilities:
Right-of-use asset	(7,056)		(7,625)
Depreciation	(1,150)		(1,478)
Beneficial conversion feature on convertible note payable	(32)		(397)
Other	(76)		(92)
Total deferred tax liabilities	(8,314)		(9,592)
Net deferred tax assets	$	—	$	—

Summary of Changes in Valuation Allowance for Deferred Tax Assets

The valuation allowance increase primarily relates to the Company's revenue recognition for tax purposes, and were as follows:

	Year Ended December 31,
	2021		2020		2019
Valuation allowance at beginning of year	$	(21,961)	$	(36,535)	$	(18,602)
Increases recorded to income tax provision	(30,616)		(11,675)		(17,933)
Decreases recorded as a benefit to income tax provision	620		26,249		—
Valuation allowance at end of year	$	(51,957)	$	(21,961)	$	(36,535)