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Income Taxes - Reconciliation of Effective Income Tax Rate (Details)
12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Effective Income Tax Rate Reconciliation, Percent [Abstract]      
Federal statutory income tax rate (21.00%) (21.00%) (35.00%)
State taxes, net of federal benefit (6.20%) (6.20%) (5.20%)
Permanent differences 0.00% 1.10% 0.30%
Stock-based compensation 1.00% 5.20% 2.60%
Research and development tax credits (7.90%) (13.70%) (0.90%)
Increase in deferred tax asset valuation allowance 33.70% 34.50% 18.60%
Other 0.40% 0.10%  
Change in statutory tax rate     19.60%