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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Cash flows from operating activities:      
Net loss $ (54,789) $ (6,597) $ (45,377)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:      
Depreciation and amortization expense 1,785 1,347 964
Stock-based compensation expense 5,991 5,217 4,709
Non-cash interest expense related to note payable 74    
Net amortization of premiums and discounts on marketable securities (764) (377) 516
Realized losses on marketable securities     2
Loss on disposal of property and equipment 1 14 35
Non-cash operating lease cost 1,814    
Changes in operating assets and liabilities:      
Amounts due from related party     5,000
Prepaid expenses and other current assets 3,001 2,170 1,088
Other assets 12 (26) (12)
Accounts payable 583 23 285
Accrued expenses and other current liabilities (710) (524) 2,945
Deferred rent   (52) 249
Operating lease liability (1,778)    
Deferred revenue - related party (15,360) (14,417) 17,174
Net cash used in operating activities (60,140) (13,222) (12,422)
Cash flows from investing activities:      
Purchases of property and equipment (1,538) (2,019) (1,973)
Purchases of marketable securities (118,347) (107,257)  
Proceeds from sales or maturities of marketable securities 136,850 72,692 27,891
Net cash provided by (used in) investing activities 16,965 (36,584) 25,918
Cash flows from financing activities:      
Payments of initial public offering costs   (2,031) (1,200)
Proceeds from initial public offering of common stock, net of commissions and underwriting discounts   100,440  
Proceeds from issuance of common stock to a related party   11,500  
Collection of note receivable from officer     62
Proceeds from issuance of convertible note payable, net of issuance costs 7,217    
Payments of debt issuance costs (81)    
Proceeds for issuance of common stock offering, net 24    
Proceeds from exercise of stock options 255 467 102
Net cash provided by (used in) financing activities 7,415 110,376 (1,036)
Net increase (decrease) in cash and cash equivalents and restricted cash (35,760) 60,570 12,460
Cash and cash equivalents and restricted cash at beginning of period 84,110 23,540 11,080
Cash and cash equivalents and restricted cash at end of period $ 48,350 84,110 23,540
Supplemental disclosure of cash flow information:      
Cash paid for income taxes   28 3,297
Supplemental disclosure of non-cash investing and financing activities:      
Accretion of redeemable convertible preferred stock to redemption value   11 40
Purchases of property and equipment included in accounts payable and accrued expenses   $ 692 450
Deferred offering costs included in accrued expenses     584
Reclassification of restricted cash from non-current assets to current assets     85
Reclassification of deposit liability for restricted stock upon vesting of shares     35
Landlord incentives for construction of leasehold improvements recorded as deferred rent     $ 2,377