Exhibit 107

Calculation of Filing Fee Tables

Form S-8

(Form Type)

Surface Oncology, Inc.

(Exact Name of Registrant as Specified in its Charter)

Table 1: Newly Registered Securities

Security Type	Security Class Title	Fee Calculation Rule	Amount Registered (1)	Proposed Maximum Offering Price Per Share	Maximum Aggregate Offering Price	Fee Rate	Amount of Registration Fee
Equity	2018 Stock Option and Incentive Plan  Common Stock, $0.0001 par value per share	457(h)	1,878,351 shares (2)	$3.62 (3)	$6,799,631	.0000927	$631
Equity	2018 Employee Stock Purchase Plan  Common Stock, $0.0001 par value per share	457(a)	469,587 shares (4)	$3.08 (5)	$1,446,328	.0000927	$135
Equity	2021 Inducement Plan  Common Stock, $0.0001 par value per share	457(h)	600,000 shares (6)	$3.62 (3)	$2,172,000	.0000927	$202
Total Offering Amounts					$10,417,959		$968
Total Fee Offsets							$0
Net Fee Due							$968

(1) Pursuant to Rule 416 under the Securities Act of 1933, as amended (the “Securities Act”), this Registration Statement shall also cover any additional shares of common stock which become issuable under the above-named plans by reason of any stock dividend, stock split, recapitalization or any other similar transaction effected without the receipt of consideration which results in an increase in the number of our outstanding shares of common stock. Pursuant to Rule 416(c) under the Securities Act, this Registration Statement shall also cover an indeterminate amount of interests to be offered or sold pursuant to the employee benefit plans described herein.

(2) Represents an automatic annual increase on January 1, 2022 to the number of shares reserved for issuance under the 2018 Stock Option and Incentive Plan (the “2018 Plan”) pursuant to the terms of the 2018 Plan. Shares available for issuance under the 2018 Plan were previously registered on a

registration statement on Form S-8 filed with the Securities and Exchange Commission (“SEC”) on April 23, 2018 (Registration No. 333-224403), a registration statement on Form S-8 filed with the SEC on March 7, 2019 (Registration No. 333-230129), a registration statement on Form S-8 filed with the SEC on March 10, 2020 (Registration No. 333-237044) and a registration statement on Form S-8 filed with the SEC on March 9, 2021 (Registration No. 333-254023).

(3) Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(h) of the Securities Act, and based on $3.62, the average of the high and low sale prices of the Registrant’s common stock as reported on the Nasdaq Global Market on February 28, 2022.

(4) Represents an automatic annual increase on January 1, 2022 to the number of shares reserved for issuance under the 2018 Employee Stock Purchase Plan (the “2018 ESPP”) pursuant to the terms of the 2018 ESPP. Shares available for issuance under the 2018 ESPP were previously registered on a registration statement on Form S-8 filed with the SEC on April 23, 2018 (Registration No. 333-224403), a registration statement on Form S-8 filed with the SEC on March 7, 2019 (Registration No. 333-230129), a registration statement on Form S-8 filed with the SEC on March 10, 2020 (Registration No. 333-237044) and a registration statement on Form S-8 filed with the SEC on March 9, 2021 (Registration No. 333-254023).

(5) Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(a) of the Securities Act, and based on 85% of $3.62 the average of the high and low sale prices of the Registrant’s common stock as reported on the Nasdaq Global Market on February 28, 2022. Pursuant to the 2018 ESPP, the purchase price of the shares of Common Stock reserved for issuance thereunder will be 85% of the fair market value of a share of Common Stock on the first trading day of the offering period or on the exercise date, whichever is less.

(6) Consists of 600,000 shares of Common Stock that may become issuable under the Registrant’s 2021 Inducement Plan pursuant to its terms.