X0306 4 2019-01-25 0001590560 uniQure N.V. QURE 0001717852 Springhorn Jeremy P. C/O UNIQURE N.V. PAASHEUVELWEG 25A AMSTERDAM P7 1105BP NETHERLANDS 1 0 0 0 Ordinary Shares 2019-01-25 4 A 0 3230 0 A 8022 D Stock Option (Right to Buy) 31.71 2019-01-25 4 A 0 5295 0 A 2029-01-25 Ordinary Shares 5295 5295 D Represents restricted share units granted to the Reporting Person under the Issuer's 2014 Share Incentive Plan, as amended and restated. Each restricted share unit represents the contingent right to receive one Ordinary Share. The restricted share units vest 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date. The Stock Option vests 100% on the first anniversary of the date of grant, subject to the Reporting Person's continued relationship with the Issuer through such date. /s/ Christian Klemt, Attorney-in-Fact 2019-01-29