144 0002024169 XXXXXXXX LIVE 0001717115 TEMPUS AI, INC. 001-42130 600 WEST CHICAGO AVENUE, SUITE 510 CHICAGO IL 60654 800-976-5448 Andrew Polovin Officer Class A Common Stock Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza, 8th Floor New York NY 10004

9797 624460.78 168072456 05/20/2025 NASDAQ Class A Common Stock 04/27/2022 Restricted Stock Units Issuer N 1642 04/27/2022 N/A Class A Common Stock 04/18/2023 Restricted Stock Units Issuer N 559 04/18/2023 N/A Class A Common Stock 07/18/2023 Restricted Stock Units Issuer N 2234 07/18/2023 N/A Class A Common Stock 05/02/2024 Restricted Stock Units Issuer N 2979 05/02/2024 N/A Class A Common Stock 02/24/2025 Restricted Stock Units Issuer N 2383 02/24/2025 N/A N 10b5-1 Sales for ANDREW POLOVIN

600 WEST CHICAGO AVENUE, Suite 510 CHICAGO IL 60654

Class A Common Stock 03/21/2025 3076 153800.00 10b5-1 Sales for ANDREW POLOVIN

600 WEST CHICAGO AVENUE, Suite 510 CHICAGO IL 60654

Class A Common Stock 03/18/2025 13135 603903.95 The sales reported on this Form 144 are mandated by the Issuer's election under its equity incentive plan to require the satisfaction of a tax withholding obligation to be funded by sell to cover transactions and do not represent discretionary trades by the reporting person. 05/21/2025 /s/ Andrew Polovin