<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>SCHEDULE 13G</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: ARK Investment Management LLC -->
          <cik>0001697748</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>02/28/2026</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001717115</issuerCik>
        <issuerName>Tempus AI, Inc.</issuerName>
        <issuerCusip>88023B103</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>600 West Chicago Avenue</com:street1>
          <com:street2>Suite 510</com:street2>
          <com:city>Chicago</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60654</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(b)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>ARK Investment Management LLC</reportingPersonName>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>8836759.00</soleVotingPower>
        <sharedVotingPower>185573.00</sharedVotingPower>
        <soleDispositivePower>9446435.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>9446435.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>5.44</classPercent>
      <typeOfReportingPerson>IA</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>Catherine D. Wood</reportingPersonName>
      <citizenshipOrOrganization>X1</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>9022332.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>9446435.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>9446435.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>5.44</classPercent>
      <typeOfReportingPerson>HC</typeOfReportingPerson>
      <typeOfReportingPerson>IN</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>Tempus AI, Inc.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>600 West Chicago Avenue, Suite 510, Chicago, IL 60654</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>(i) ARK Investment Management LLC ("ARK")
(ii) Catherine D. Wood</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>ARK and Catherine D. Wood: 200 Central Avenue, St. Petersburg, FL 33701</principalBusinessOfficeOrResidenceAddress>
        <citizenship>(i) ARK: Delaware
(ii) Catherine D. Wood: United States</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>N</notApplicableFlag>
        <typeOfPersonFiling>IA</typeOfPersonFiling>
        <typeOfPersonFiling>HC</typeOfPersonFiling>
      </item3>
      <item4>
        <amountBeneficiallyOwned>ARK and Catherine D. Wood: 9,446,435</amountBeneficiallyOwned>
        <classPercent>ARK and Catherine D. Wood: 5.44</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>(i) ARK: 8,836,759
(ii) Catherine D. Wood: 0</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>(i) ARK: 185,573
(ii) Catherine D. Wood: 9,022,332</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>(i) ARK: 9,446,435
(ii) Catherine D. Wood: 0</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>(i) ARK: 0
(ii) Catherine D. Wood: 9,446,435</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>ARK Investment Management LLC</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Kellen Carter</signature>
        <title>Kellen Carter, Chief Compliance Officer</title>
        <date>03/06/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Catherine D. Wood</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Catherine D. Wood</signature>
        <title>Catherine D. Wood, Chief Executive Officer, Chief Investment Officer</title>
        <date>03/06/2026</date>
      </signatureDetails>
    </signatureInformation>
  </formData>

</edgarSubmission>
