X0206 3 2022-04-18 0 0001716947 Ensysce Biosciences, Inc. ENSC 0001926732 Osman Nilab C/O ENSYSCE BIOSCIENCES, INC. 7946 IVANHOE AVENUE, SUITE 201 LA JOLLA CA 92037 0 1 0 0 Chief Medical Officer Stock Option 1.07 2032-04-18 Common Stock 200000 D On April 18, 2022, Dr. Osman appointed Chief Medical Officer of Ensysce Biosciences, Inc. In connection with her employment, on April 18, 2022, Dr. Osman was granted an option (the "Stock Option") to purchase 200,000 shares of common stock of Ensysce Biosciences, Inc., par value $0.0001 per share, with an exercise price of $1.07. Twenty-five percent of the Stock Option is scheduled to vest on April 18, 2023, with the remaining shares vesting in equal monthly installments over the thirty-six months thereafter. /s/Osman Nilab 2022-04-28