SCHEDULE 13G/A 0001224962 XXXXXXXX LIVE 3 Common Stock, par value $0.0001 per share 03/31/2025 0001716947 Ensysce Biosciences, Inc. 293602504 7946 Ivanhoe Avenue Suite 201 La Jolla CA 92037 Rule 13d-1(c) Perceptive Advisors LLC DE 0 86666 0 86666 86666 N 3.7 IA Joseph Edelman X1 0 86666 0 86666 86666 N 3.7 IN Perceptive Life Sciences Master Fund, Ltd. E9 0 86666 0 86666 86666 N 3.7 CO Ensysce Biosciences, Inc. 7946 Ivanhoe Avenue, Suite 201, La Jolla, CA 92037 The names of the persons filing this report (collectively, the "Reporting Persons") with respect to shares of Common Stock, par value $0.0001 per share (the "Common Stock") of Ensysce Biosciences, Inc. (the "Issuer") are: (i) Perceptive Advisors LLC ("Perceptive Advisors") (ii) Joseph Edelman ("Mr. Edelman") (iii) Perceptive Life Sciences Master Fund, Ltd. (the "Master Fund") The address of the principal business office of each of the Reporting Persons is: 51 Astor Place, 10th Floor, New York, NY 10003 Perceptive Advisors is a Delaware limited liability company. Mr. Edelman is a United States citizen. The Master Fund is a Cayman Islands corporation. Y The information required by this item with respect to each Reporting Person is set forth in Rows 5 through 9 of the cover pages to this Schedule 13G. The ownership percentages reported are based on 2,370,698 shares of Common Stock outstanding as of April 28, 2025, as reported in the Issuer's registration statement on Form S-3 filed with the Securities and Exchange Commission on May 2, 2025. The Master Fund directly holds 86,666 shares of Common Stock. Perceptive Advisors serves as the investment manager to the Master Fund and may be deemed to beneficially own such shares. Mr. Edelman is the managing member of Perceptive Advisors and may be deemed to beneficially own such shares. Perceptive Advisors: 3.7% Mr. Edelman: 3.7% Master Fund: 3.7 Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 Perceptive Advisors: 86,666 Mr. Edelman: 86,666 Master Fund: 86,666 Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 Perceptive Advisors: 86,666 Mr. Edelman: 86,666 Master Fund: 86,666 N Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Perceptive Advisors LLC /s/ Joseph Edelman 05/15/2025 Joseph Edelman /s/ Joseph Edelman 05/15/2025 Perceptive Life Sciences Master Fund, Ltd. /s/ Joseph Edelman 05/15/2025