Stock-Based Compensation (Tables)

9 Months Ended

12 Months Ended

Sep. 30, 2021

Dec. 31, 2020

Share Based Compensation Arrangement By Share Based Payment Award [Line Items]

Schedule of Restricted Stock Units Activity

A summary of the restricted stock unit activity under the 2018 Plan is presented below:

	Restricted Stock Units			Weighted Average Grant Date Fair Value
Outstanding at December 31, 2020		33,548		$	21.93
Granted		29,614		$	3.99
Vested		(1,845	)	$	64.80
Forfeited		(15,485	)	$	14.67
Outstanding at September 30, 2021		45,832		$	11.06

A summary of the activity and related information of the restricted stock units is presented below:

	Restricted Stock Units			Weighted Average Grant Date Fair Value
Outstanding at December 31, 2018		59,767		$	672.75
Granted		12,010			98.75
Vested and released		(48,269	)		698.25
Forfeited		(12,644	)		497.75
Outstanding at December 31, 2019		10,864		$	128.82
Granted		32,019			10.82
Vested and released		(7,906	)		114.55
Forfeited		(1,429	)		101.79
Outstanding at December 31, 2020		33,548		$	21.93

Schedule of Restricted Stock Awards Activity

A summary of the activity and related information of the restricted stock awards is presented below:

	Restricted Stock Awards (in shares)		Weighted Average Grant Date Fair Value
Outstanding at December 31, 2019		—	$	—
Granted		286,161		4.77
Forfeited		—		—
Vested		—		—
Outstanding at December 31, 2020		286,161	$	4.77

Schedule of Stock-based Compensation Expense Recorded in Operating Expenses

Stock-based compensation expense recorded in operating expenses was as follows (in thousands):

	Three Months Ended September 30,				Nine Months Ended September 30,
	2021		2020		2021		2020
Selling, general and administrative	$	78	$	757	$	1,551	$	2,424
Research and development		27		115		251		317
Stock-based compensation in operating expenses	$	105	$	872	$	1,802	$	2,741

Stock-based compensation expense recorded in operating expenses was as follows (in thousands):

	Year Ended December 31,
	2020		2019
Selling, general and administrative	$	3,235	$	16,141
Research and development		444		1,537
Stock-based compensation in operating expenses	$	3,679	$	17,678

Stock Options [Member]

Share Based Compensation Arrangement By Share Based Payment Award [Line Items]

Schedule of Options Activity

A summary of the stock option activity under the 2018 Equity Incentive Plan (the “2018 Plan”) and the 2018 Stock Compensation Plan is presented below:

	Stock Options			Weighted Average Exercise Price		Weighted Average Remaining Life (in years)		Aggregate Intrinsic Value (in thousands)
Outstanding at December 31, 2020		124,171		$	363.31		6.42
Forfeited		(15,173	)	$	87.28
Outstanding at September 30, 2021		108,998		$	401.74		4.82	$	—
Exercisable at September 30, 2021		95,096		$	455.95		4.32	$	—
Vested and expected to vest at September 30, 2021		108,998		$	401.74		4.80	$	—

A summary of the activity and related information of the stock options issued under the 2018 Equity Incentive Plan and the Compensation Plan is presented below:

	Stock Options			Weighted Average Exercise Price		Weighted Average Remaining Life (in years)		Aggregate Intrinsic Value (in thousands)
Outstanding at December 31, 2018		76,804		$	714.75		9.43	$	—
Granted		60,854			30.50
Forfeited		(12,079	)		670.25
Outstanding at December 31, 2019		125,579		$	387.50		9.43	$	—
Granted		11,729			30.69
Forfeited		(13,137	)		297.57
Outstanding at December 31, 2020		124,171		$	363.31		6.42	$	—
Exercisable at December 31, 2020		84,376		$	466.78		5.89	$	—
Vested and expected to vest at December 31, 2020		124,171		$	363.31		6.42	$	—

Stock Option Activity Two Thousand Twenty Equity Incentive Plan [Member]

Share Based Compensation Arrangement By Share Based Payment Award [Line Items]

Schedule of Options Activity

A summary of the stock option activity under the 2020 Inducement Equity Incentive Plan (the “2020 Plan”) is presented below:

	Stock Options		Weighted Average Exercise Price		Weighted Average Remaining Life (in years)		Aggregate Intrinsic Value (in thousands)
Outstanding at December 31, 2020		18,000	$	25.50		9.24
Outstanding at September 30, 2021		18,000	$	25.50		8.50	$	—
Exercisable at September 30, 2021		6,750	$	25.50		8.50	$	—
Vested and expected to vest at September 30, 2021		18,000	$	25.50		8.50	$	—

Two Thousand Eighteen Restricted Stock Plan

Share Based Compensation Arrangement By Share Based Payment Award [Line Items]

Schedule of Restricted Stock Awards Activity

A summary of the restricted stock award activity under the 2018 Plan is presented below:

	Restricted Stock Awards			Weighted Average Grant Date Fair Value
Outstanding at December 31, 2020		286,161		$	4.77
Granted		103,939		$	4.82
Vested		(31,388	)	$	6.96
Forfeited		(50,082	)	$	5.10
Outstanding at September 30, 2021		308,630		$	4.51

Schedule of Fair Value of Options Using the Black Scholes Option Pricing Model and Assumptions Used

The fair value of the stock options issued under the 2018 Plan was estimated using the Black Scholes option pricing model and the weighted-average assumptions used in the model are noted in the following table:

	Year Ended December 31,
	2020			2019
Risk-free interest rate		1.3	%		1.6	%
Volatility		58.96	%		59.26	%
Expected dividend yield		0.00	%		0.00	%
Expected life (in years)		5.8			5.9

Two Thousand Twenty Restricted Stock Plan

Share Based Compensation Arrangement By Share Based Payment Award [Line Items]

Schedule of Restricted Stock Awards Activity

A summary of the restricted stock award activity under the 2020 Plan is presented below:

	Restricted Stock Awards			Weighted Average Grant Date Fair Value
Outstanding at December 31, 2020		4,375		$	25.50
Vested		(625	)	$	25.50
Outstanding at September 30, 2021		3,750		$	25.50

Schedule of Fair Value of Options Using the Black Scholes Option Pricing Model and Assumptions Used

The fair value of the stock options issued under the 2020 Plan was estimated using the Black Scholes option pricing model and the weighted-average assumptions used in the model are noted in the following table:

	Year Ended December 31,
	2020
Risk-free interest rate		0.5	%
Volatility		58.33	%
Expected dividend yield		0.00	%
Expected life (in years)		6.3