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    <periodOfReport>2019-02-04</periodOfReport>

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    <issuer>
        <issuerCik>0001658247</issuerCik>
        <issuerName>Crinetics Pharmaceuticals, Inc.</issuerName>
        <issuerTradingSymbol>CRNX</issuerTradingSymbol>
    </issuer>

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            <rptOwnerName>Versant Venture Capital V, L.P.</rptOwnerName>
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        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE SANSOME STREET, SUITE 3630</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94104</rptOwnerZipCode>
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    <reportingOwner>
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            <rptOwnerCik>0001589095</rptOwnerCik>
            <rptOwnerName>Versant Affiliates Fund V, L.P.</rptOwnerName>
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            <rptOwnerStreet1>ONE SANSOME STREET, SUITE 3630</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
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    <reportingOwner>
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            <rptOwnerName>Versant Ophthalmic Affiliates I, L.P.</rptOwnerName>
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            <rptOwnerStreet1>ONE SANSOME STREET, SUITE 3630</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
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    <reportingOwner>
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            <rptOwnerName>Versant Venture Capital V (Canada), LP</rptOwnerName>
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            <rptOwnerStreet1>ONE SANSOME STREET, SUITE 3630</rptOwnerStreet1>
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            <rptOwnerState>CA</rptOwnerState>
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    <reportingOwner>
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            <rptOwnerStreet1>ONE SANSOME STREET, SUITE 3630</rptOwnerStreet1>
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            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94104</rptOwnerZipCode>
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    <reportingOwner>
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            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
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    <footnotes>
        <footnote id="F1">Represents a pro-rata in-kind distribution of Common Stock of the Issuer by Versant Venture Capital V, L.P. (&quot;VVC V&quot;) without consideration to its partners.</footnote>
        <footnote id="F2">These securities are held of record by VVC V.  Versant Ventures V, LLC (&quot;VV V&quot;) is the sole general partner of VVC V and may be deemed to have voting and investment power over the securities held by VVC V and as a result may be deemed to have beneficial ownership over such securities. Samuel D. Colella, William J. Link, Bradley Bolzon, Ph.D., Robin L. Praeger, Kirk G. Nielson and Thomas Woiwode, Ph.D. are managing directors of VV V and share voting and dispositive power over the shares held by VVC V; however, they each disclaim beneficial ownership of the shares held by VVC V, except to the extent of their pecuniary interests therein.</footnote>
        <footnote id="F3">Represents a pro-rata in-kind distribution of Common Stock of the Issuer by Versant Affiliates Fund V, L.P. (&quot;VAF V&quot;) without consideration to its partners.</footnote>
        <footnote id="F4">These securities are held of record by VAF V. VV V is the sole general partner of VAF V and may be deemed to have voting and investment power over the securities held by VAF V and as a result may be deemed to have beneficial ownership over such securities. Samuel D. Colella, William J. Link, Bradley Bolzon, Ph.D., Robin L. Praeger, Kirk G. Nielson and Thomas Woiwode, Ph.D. are managing directors of VV V and share voting and dispositive power over the shares held by VAF V; however, they each disclaim beneficial ownership of the shares held by VAF V, except to the extent of their pecuniary interests therein.</footnote>
        <footnote id="F5">Represents a pro-rata in-kind distribution of Common Stock of the Issuer by Versant Ophthalmic Affiliates Fund I, L.P. (&quot;VOA&quot;) without consideration to its partners.</footnote>
        <footnote id="F6">These securities are held of record by VOA. VV V is the sole general partner of VOA and may be deemed to have voting and investment power over the securities held by VOA and as a result may be deemed to have beneficial ownership over such securities. Samuel D. Colella, William J. Link, Bradley Bolzon, Ph.D., Robin L. Praeger, Kirk G. Nielson and Thomas Woiwode, Ph.D. are managing directors of VV V and share voting and dispositive power over the shares held by VOA; however, they each disclaim beneficial ownership of the shares held by VOA, except to the extent of their pecuniary interests therein.</footnote>
        <footnote id="F7">Represents a pro-rata in-kind distribution of Common Stock of the Issuer by Versant Venture Capital V (Canada) LP (&quot;VVC CAN&quot;)  without consideration to its partners.</footnote>
        <footnote id="F8">These securities are held of record by VVC CAN. Versant Ventures V GP-GP (Canada), Inc. (&quot;VV V CAN GP&quot;) is the sole general partner of Versant Ventures V (Canada), L.P. (&quot;VV V CAN&quot;) and VV V CAN is the sole general partner of VVC CAN. By virtue of such relationships, VV V CAN GP and VV V CAN may be deemed to have voting and investment power over the securities held by VVC CAN and as a result may be deemed to have beneficial ownership over such securities. Samuel D. Colella, William J. Link, Bradley Bolzon, Ph.D., Robin L. Praeger, Kirk G. Nielson and Thomas Woiwode, Ph.D. are directors of VV V CAN GP and share voting and dispositive power over the shares held by VVC CAN; however, they each disclaim beneficial ownership of the shares held by VVC CAN, except to the extent of their pecuniary interests therein.</footnote>
        <footnote id="F9">Represents a change in the form of ownership of VV V by virtue of the receipt of shares in the pro-rata in-kind distribution of Common Stock of the Issuer for no consideration by VVC V, VAF V and VOA.</footnote>
        <footnote id="F10">The shares are held VV V.</footnote>
        <footnote id="F11">Represents a pro-rata in-kind distribution of Common Stock of the Issuer by VV V without consideration to its members.</footnote>
        <footnote id="F12">Represents a change in the form of ownership of VV V CAN by virtue of the receipt of shares in the pro-rata in-kind distribution of Common Stock of the Issuer for no consideration by VVC CAN.</footnote>
        <footnote id="F13">The shares are held VV V CAN.</footnote>
        <footnote id="F14">Represents a pro-rata in-kind distribution of Common Stock of the Issuer by VV V CAN without consideration to its partners.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>VERSANT VENTURE CAPITAL V, L.P. By: Versant Ventures V, LLC Its: General Partner By: /s/ Robin L. Praeger</signatureName>
        <signatureDate>2019-02-06</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>VERSANT AFFILIATES FUND V, L.P. By: Versant Ventures V, LLC Its: General Partner By: /s/ Robin L. Praeger</signatureName>
        <signatureDate>2019-02-06</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>VERSANT OPHTHALMIC AFFILIATES FUND I, L.P. By: Versant Ventures V, LLC Its: General Partner By: /s/ Robin L. Praeger</signatureName>
        <signatureDate>2019-02-06</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>VERSANT VENTURE CAPITAL V (CANADA) LP By: Versant Ventures V (Canada), L.P. Its: General Partner By: Versant Ventures V GP-GP (Canada), Inc. Its: General Partner By: /s/ Robin L. Praeger</signatureName>
        <signatureDate>2019-02-06</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>VERSANT VENTURES V, LLC By: /s/ Robin L. Praeger</signatureName>
        <signatureDate>2019-02-06</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>VERSANT VENTURES V (CANADA), L.P. By: Versant Ventures V GP-GP (Canada), Inc. Its: General Partner By: /s/ Robin L. Praeger</signatureName>
        <signatureDate>2019-02-06</signatureDate>
    </ownerSignature>
</ownershipDocument>
