X0508 4 2025-06-13 0001401667 PUMA BIOTECHNOLOGY, INC. PBYI 0001716328 Stuglik Brian M C/O PUMA BIOTECHNOLOGY, INC. 10880 WILSHIRE BOULEVARD, SUITE 2150 LOS ANGELES CA 90024 1 1 Common Stock 2025-06-13 4 S 0 8100 3.39 D 94958 D Adoption date of referenced 10b5-1(c) plan is: 03/12/2025 The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.34 to $3.46, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote. /s/ Gordon Esplin as attorney-in-fact for Brian M. Stuglik 2025-06-17