<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001715344</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001142417</issuerCik>
      <issuerName>NEXSTAR MEDIA GROUP, INC.</issuerName>
      <secFileNumber>000-50478</secFileNumber>
      <issuerAddress>
        <com:street1>545 EAST JOHN CARPENTER FREEWAY</com:street1>
        <com:street2>SUITE 700</com:street2>
        <com:city>IRVING</com:city>
        <com:stateOrCountry>TX</com:stateOrCountry>
        <com:zipCode>75062</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>972-373-8800</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>ALFORD ANDREW</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>900 Salem Street</com:street1>
          <com:city>Smithfield</com:city>
          <com:stateOrCountry>RI</com:stateOrCountry>
          <com:zipCode>02917</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>751</noOfUnitsSold>
      <aggregateMarketValue>125603.55</aggregateMarketValue>
      <noOfUnitsOutstanding>30148875</noOfUnitsOutstanding>
      <approxSaleDate>06/04/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>06/03/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>751</amountOfSecuritiesAcquired>
      <paymentDate>06/03/2025</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Andy Alford</name>
        <address>
          <com:street1>545 E. John Carpenter Freeway</com:street1>
          <com:street2>Suite 700</com:street2>
          <com:city>Irving</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>75062</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>03/26/2025</saleDate>
      <amountOfSecuritiesSold>3768</amountOfSecuritiesSold>
      <grossProceeds>685716.47</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Andy Alford</name>
        <address>
          <com:street1>545 E. John Carpenter Freeway</com:street1>
          <com:street2>Suite 700</com:street2>
          <com:city>Irving</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>75062</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>05/20/2025</saleDate>
      <amountOfSecuritiesSold>838</amountOfSecuritiesSold>
      <grossProceeds>147092.80</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Andy Alford</name>
        <address>
          <com:street1>545 E. John Carpenter Freeway</com:street1>
          <com:street2>Suite 700</com:street2>
          <com:city>Irving</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>75062</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>05/27/2025</saleDate>
      <amountOfSecuritiesSold>779</amountOfSecuritiesSold>
      <grossProceeds>135229.18</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>Sale includes an amount necessary to cover a tax obligation resulting from the settlement of a vested equity award distribution.</remarks>
    <noticeSignature>
      <noticeDate>06/04/2025</noticeDate>
      <signature>/s/ Jared Cook, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Andy Alford</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
