Income Taxes - Narrative (Details)	12 Months Ended
	Dec. 31, 2025 USD ($)
Operating Loss Carryforwards [Line Items]
Net valuation allowance increase	$ 143,100,000
Unrecognized tax benefits that would reduce the annual effective tax rate, if recognized	0
Liability recorded for potential interest or penalties	0
Expected change to unrecognized tax benefit	0
Federal authority
Operating Loss Carryforwards [Line Items]
Net operating loss carryforward	964,900,000
Federal authority | Research Tax Credit Carryforward
Operating Loss Carryforwards [Line Items]
Tax credit carryforward	73,800,000
Federal authority | Orphan Drug Tax Credit Carryforward
Operating Loss Carryforwards [Line Items]
Tax credit carryforward	75,000,000.0
State authority
Operating Loss Carryforwards [Line Items]
Net operating loss carryforward	398,400,000
Tax credit carryforward	$ 55,100,000