Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Total	Common Stock	Additional Paid-in Capital	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2022		135,965,918
Beginning balance at Dec. 31, 2022	$ 1,042,430	$ 1,686	$ 2,018,617	$ (6,886)	$ (970,987)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuances under equity incentive plans (in shares)		1,232,526
Issuances under equity incentive plans	17,820	$ 12	17,808
Vesting of restricted stock units (in shares)		1,187,054
Vesting of restricted stock units	0	$ 13	(13)
Stock-based compensation	108,399		108,399
Net loss	(145,224)				(145,224)
Other comprehensive income (loss)	7,529			7,529
Ending balance (in shares) at Dec. 31, 2023		138,385,498
Ending balance at Dec. 31, 2023	1,030,954	$ 1,711	2,144,811	643	(1,116,211)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock and pre-funded warrants, net of issuance costs (in shares)		3,244,689
Issuance of common stock and pre-funded warrants, net of issuance costs	499,253	$ 32	499,221
Issuances under equity incentive plans (in shares)		1,288,609
Issuances under equity incentive plans	17,389	$ 13	17,376
Vesting of restricted stock units (in shares)		1,302,190
Vesting of restricted stock units	0	$ 12	(12)
Stock-based compensation	103,484		103,484
Net loss	(422,773)				(422,773)
Other comprehensive income (loss)	$ 1,377			1,377
Ending balance (in shares) at Dec. 31, 2024	144,220,986	144,220,986
Ending balance at Dec. 31, 2024	$ 1,229,684	$ 1,768	2,764,880	2,020	(1,538,984)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock and pre-funded warrants, net of issuance costs (in shares)		9,142,857
Issuance of common stock and pre-funded warrants, net of issuance costs	189,249	$ 91	189,158
Issuances under equity incentive plans (in shares)		1,368,573
Issuances under equity incentive plans	8,459	$ 14	8,445
Vesting of restricted stock units (in shares)		1,449,761
Vesting of restricted stock units	0	$ 15	(15)
Stock-based compensation	100,247		100,247
Net loss	(512,540)				(512,540)
Other comprehensive income (loss)	$ (1,338)			(1,338)
Ending balance (in shares) at Dec. 31, 2025	156,182,177	156,182,177
Ending balance at Dec. 31, 2025	$ 1,013,761	$ 1,888	$ 3,062,715	$ 682	$ (2,051,524)