Stock-Based Awards - Schedule of Stock-Based Compensation Expense (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total	$ 99,633	$ 102,878	$ 108,102
Research and development
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total	59,490	59,146	62,901
General and administrative
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total	$ 40,143	$ 43,732	$ 45,201