Stock-Based Awards (Tables)

12 Months Ended

Dec. 31, 2025

Share-Based Payment Arrangement [Abstract]

Schedule of Stock Option Activity

The following table summarizes option award activity under the 2017 Plan and the 2015 Plan: 

	Number of Options	Weighted- Average Exercise Price		Weighted- Average remaining contractual life (years)	Aggregate Intrinsic Value (in thousands)
Balance at December 31, 2024	18,660,150	$	25.99	5.94	$	48,266
Granted	5,019,276	19.57
Exercised	(773,881)	1.81
Forfeited	(734,841)	25.16
Expired	(844,371)	0.68
Balance at December 31, 2025	21,326,333	$	26.39	6.21	$	10,658
Vested and expected to vest at December 31, 2025	21,326,333	$	26.39	6.21	$	10,658
Exercisable at December 31, 2025	13,674,635	$	29.46	4.84	$	8,497

Schedule of Assumptions Used for Estimating the Fair Value of Stock Granted

The following assumptions were used in estimating the fair value of grants during the year ended:

	December 31,
	2025	2024	2023
Expected term (in years)	5.50 - 6.08	5.50 - 6.08	5.50 - 6.08
Volatility	64.8% - 68.7%	64.5% - 66.0%	67.6% - 69.6%
Risk-free interest rate	3.6% - 4.5%	3.7% - 4.5%	3.4% - 4.8%
Dividend yield	—	—	—

Schedule of Restricted Stock Activity

Aggregated information regarding RSUs granted under the Plan for the year ended December 31, 2025 is summarized below:

	Number of Units	Weighted-Average Fair Value at Date of Grant per Share
Unvested at December 31, 2024	4,128,514	$	27.33
Granted	2,726,354	18.76
Vested and released	(1,449,761)	32.12
Forfeited	(280,478)	21.49
Unvested and expected to vest at December 31, 2025	5,124,629	$	21.74

Schedule of Stock-Based Compensation Expense

The Company’s stock-based compensation expense was as follows (in thousands):

	Year Ended December 31,
	2025		2024		2023
Research and development	$	59,490	$	59,146	$	62,901
General and administrative	40,143		43,732		45,201
Total	$	99,633	$	102,878	$	108,102