144 0001724605 XXXXXXXX LIVE 0001714899 Denali Therapeutics Inc. 001-38311 161 OYSTER POINT BLVD, SOUTH SAN FRANCISCO CA 94080 6508668548 Ho Carole Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 38th Fl. New York NY 10004

12255 247785.71 144215778 01/06/2025 NASDAQ Common 01/03/2025 Restricted Stock Lapse - See Remarks Denali Therapeutics Inc. N 12255 01/03/2025 Equity Compensation Y Shares sold to cover tax obligation from settlement of vested Restricted Stock Units. 01/07/2025 /s/ Tyler Nielsen, by power of attorney