Income Taxes - Narrative (Details) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Operating Loss Carryforwards [Line Items]
Deferred tax asset, research and development TCJA adjustment	$ 61,869,000	$ 0
Valuation allowance against net deferred tax assets (as a percentage)	100.00%	100.00%
Net valuation allowance increase	$ 104,000,000
Unrecognized tax benefits that would reduce the annual effective tax rate, if recognized	0
Liability recorded for potential interest or penalties	0
Expected change to unrecognized tax benefit	0
Federal authority
Operating Loss Carryforwards [Line Items]
Net operating loss carryforward	231,900,000
Federal authority | Research Tax Credit Carryforward
Operating Loss Carryforwards [Line Items]
Tax credit carryforward	42,600,000
Federal authority | Orphan Drug Tax Credit Carryforward
Operating Loss Carryforwards [Line Items]
Tax credit carryforward	19,700,000
State authority
Operating Loss Carryforwards [Line Items]
Net operating loss carryforward	267,000,000
Tax credit carryforward	$ 31,400,000