Stock-Based Awards - Summary of Stock-Based Compensation Expense (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total	$ 99,847	$ 85,247	$ 50,351
Research and development
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total	60,196	50,036	29,002
General and administrative
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total	$ 39,651	$ 35,211	$ 21,349