X0306 4 2021-06-02 0 0001714899 Denali Therapeutics Inc. DNLI 0001486373 Cole Douglas G. C/O FLAGSHIP PIONEERING 55 CAMBRIDGE PARKWAY, SUITE 800E CAMBRIDGE MA 02142 1 0 0 0 Common Stock 2021-06-02 4 A 0 2074 0.00 A 5327 D Stock Option (right to buy) 63.76 2021-06-02 4 A 0 6222 0.00 A 2031-06-02 Common Stock 6222 6222 D Each share is represented by a Restricted Stock Unit ("RSU") and a contingent right to receive one share of common stock of the Issuer. 100% of the RSUs shall vest upon the earlier of (i) the one year anniversary of the grant date or (ii) the day preceding the Issuer's next annual meeting of stockholders occurring after the grant date. 100% of the shares subject to the option shall vest upon the earlier of (i) the one year anniversary of the grant date or (ii) the day preceding the Issuer's next annual meeting of stockholders occurring after the grant date. /s/ Tyler Nielsen, by power of attorney 2021-06-04