X0306 4 2021-06-01 0 0001714899 Denali Therapeutics Inc. DNLI 0001578200 Schenkein David P C/O DENALI THERAPEUTICS INC. 161 OYSTER POINT BLVD. SOUTH SAN FRANCISCO CA 94080 1 0 0 0 Common Stock 2021-06-01 4 M 0 3253 0.00 A 3253 D Common Stock 26232 I See footnote Common Stock 31232 I See footnote Restricted Stock Units 2021-06-01 4 M 0 3253 0.00 D Common Stock 3253 0 D The shares are held of record by the David P. Schenkein 2004 Revocable Trust, for which the Reporting Person serves as a trustee. The shares are held of record by the Amy P. Schenkein 2004 Revocable Trust, for which the Reporting Person's spouse serves as a trustee. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. 100% of the restricted stock units shall vest upon the earlier of (i) the one year anniversary of the grant date or (ii) the day preceding the Issuer's next annual meeting of stockholders occurring after the grant date. /s/ Tyler Nielsen, by power of attorney 2021-06-03