X0306 4 2021-06-01 0 0001714899 Denali Therapeutics Inc. DNLI 0001189130 FLATLEY JAY T C/O DENALI THERAPEUTICS INC. 161 OYSTER POINT BLVD. SOUTH SAN FRANCISCO CA 94080 1 0 0 0 Common Stock 2021-06-01 4 M 0 3253 0.00 A 328253 I See footnote Restricted Stock Units 2021-06-01 4 M 0 3253 0.00 D Common Stock 3253 0 D Shares were issued directly to The Flatley Family Trust. The shares are held of record by The Flatley Family Trust, for which the Reporting Person serves as a trustee. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. 100% of the restricted stock units vest upon the earlier of (i) the one year anniversary of the grant date or (ii) the day preceding the Issuer's next annual meeting of stockholders occurring after the grant date. /s/ Tyler Nielsen, by power of attorney 2021-06-03