X0306 4 2021-05-26 0 0001714899 Denali Therapeutics Inc. DNLI 0001197020 SATO VICKI L C/O DENALI THERAPEUTICS INC. 161 OYSTER POINT BLVD. SOUTH SAN FRANCISCO CA 94080 1 0 0 0 Common Stock 2021-05-26 4 S 0 894 64.902 D 134861 D Common Stock 2021-05-26 4 S 0 732 65.875 D 134129 D Common Stock 2021-05-26 4 S 0 40 66.715 D 134089 D The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan. The sale price reported in column 4 of Table I represents the weighted average sale price of the shares ranging from $64.58 to $65.57 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price. Includes 3,253 restricted stock units. The sale price reported in column 4 of Table I represents the weighted average sale price of the shares ranging from $65.60 to $66.53 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price. The sale price reported in column 4 of Table I represents the weighted average sale price of the shares ranging from $66.60 to 66.83 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price. /s/ Tyler Nielsen, by power of attorney 2021-05-28