X0306 4 2020-10-08 0 0001714899 Denali Therapeutics Inc. DNLI 0001724605 Ho Carole C/O DENALI THERAPEUTICS INC. 161 OYSTER POINT BLVD. SOUTH SAN FRANCISCO CA 94080 0 1 0 0 Chief Medical Officer Common Stock 2020-10-08 4 M 0 22906 5.28 A 189523 I See footnote Common Stock 2020-10-08 4 S 0 22906 40.12 D 166617 I See footnote Common Stock 2020-10-09 4 M 0 30000 5.28 A 196617 I See footnote Common Stock 2020-10-09 4 S 0 10465 40.68 D 186152 I See footnote Common Stock 2020-10-09 4 S 0 19535 41.51 D 166617 I See footnote Common Stock 25000 I See footnote Stock Option (right to buy) 5.28 2020-10-08 4 M 0 13020 0.00 D 2026-07-01 Common Stock 13020 44035 D Stock Option (right to buy) 5.28 2020-10-08 4 M 0 9886 0.00 D 2027-03-07 Common Stock 9886 68240 D Stock Option (right to buy) 5.28 2020-10-09 4 M 0 30000 0.00 D 2027-03-07 Common Stock 30000 38240 D The shares are held of record by the Rohatgi-Ho Family 2009 Revocable Trust, for which Reporting Person serves as trustee. The sales reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan. The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $40.00 to $40.32 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price. The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $40.11 to $41.09 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price. The sale price reported in column 4 of Table I represents the weighted average sale price of the shares purchased ranging from $41.11 to $41.81 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price. Shares held of record by The Rohatgi-Ho Irrevocable GST Trust. Of the total 125,000 shares granted, 25% of the shares subject to the option vested on July 2, 2017 and an additional 1/48 of the shares vest monthly thereafter. Of the total 187,500 shares granted, 25% of the shares subject to the option vested on March 8, 2018 and an additional 1/48 of the shares vest monthly thereafter. /s/ Tyler Nielsen, by power of attorney 2020-10-13