X0306 4 2020-06-03 0 0001714899 Denali Therapeutics Inc. DNLI 0001219042 NELSEN ROBERT C/O ARCH VENTURE PARTNERS 8755 W. HIGGINS ROAD, SUITE 1025 CHICAGO IL 60631 1 0 1 0 Stock Option (right to buy) 28.82 2020-06-03 4 A 0 15183 0.00 A 2030-06-02 Common Stock 15183 15183 D Restricted Stock Units 2020-06-03 4 A 0 3253 0.00 A Common Stock 3253 3253 D 100% of the shares subject to the option shall vest upon the earlier of (i) the one year anniversary of the grant date or (ii) the day preceding the Issuer's next annual meeting of stockholders occurring after the grant date. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. 100% of the restricted stock units shall vest upon the earlier of (i) the one year anniversary of the grant date or (ii) the day preceding the Issuer's next annual meeting of stockholders occurring after the grant date. /s/ Tyler Nielsen, by power of attorney 2020-06-05