X0306 4 2018-06-13 0 0001714899 Denali Therapeutics Inc. DNLI 0001486373 Cole Douglas G. C/O FLAGSHIP PIONEERING 55 CAMBRIDGE PARKWAY, SUITE 800E CAMBRIDGE MA 02142 1 0 0 0 Stock Option (right to buy) 18.92 2018-06-13 4 A 0 27830 0.00 A 2028-06-12 Common Stock 27830 27830 D 100% of the shares subject to the option shall vest upon the earlier of the one year anniversary of the grant date or the day prior to the Issuer's next annual meeting of stockholders occurring after the grant date, in each case, provided that the Reporting Person continues to serve as a non-employee director through the applicable vesting date. /s/ Tyler Nielsen, by power of attorney 2018-06-15