<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2017-07-19</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001630472</issuerCik>
        <issuerName>TPG RE Finance Trust, Inc.</issuerName>
        <issuerTradingSymbol>TRTX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001712073</rptOwnerCik>
            <rptOwnerName>Ginsberg Deborah J.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O TPG RE FINANCE TRUST, INC.,</rptOwnerStreet1>
            <rptOwnerStreet2>888 SEVENTH AVENUE, 35TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10106</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Vice President &amp; Secretary</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Class A Common Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F2"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F2"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>6790</value>
                    <footnoteId id="F1"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Explanation of Responses</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F4"/>
                    <footnoteId id="F5"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Class A Common Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F2"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F2"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>1894</value>
                    <footnoteId id="F3"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                    <footnoteId id="F5"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The 6,790 shares of Class A common stock (&quot;Class A Common Stock&quot;) of TPG RE Finance Trust, Inc. (the &quot;Issuer&quot;) reported herein include (i) 759 shares of Class A Common Stock that have been awarded by the Issuer's manager and will vest ratably in three annual installments beginning on June 30, 2018, (ii) 4,739 shares of Class A Common Stock that have been awarded by the Issuer's manager and will vest ratably in two annual installments beginning on May 5, 2018, and (iii) 1,292 shares of Class A Common Stock to be received by the Issuer's manager upon payment of a stock dividend declared by the Issuer on July 3, 2017 with respect to holders of record on that date. Upon vesting, the shares of Class A Common Stock will be delivered to Deborah Ginsberg.</footnote>
        <footnote id="F2">Pursuant to the Articles of Amendment and Restatement of the Issuer, each share of Class A Common Stock is convertible at any time or from time to time, at the option of the holder, for one share of common stock (&quot;Common Stock&quot;) of the Issuer.</footnote>
        <footnote id="F3">Includes 360 shares of Class A Common Stock to be received by Ms. Ginsberg upon payment of a stock dividend declared by the Issuer on July 3, 2017 with respect to holders of record on that date.</footnote>
        <footnote id="F4">Ms. Ginsberg is a TPG Managing Director.  TPG is affiliated with TPG Holdings III, L.P., TPG/NJ (RE) Partnership, L.P., TPG RE Finance Trust Management, L.P. and TPG RE Finance Trust Equity, L.P. (collectively, the &quot;TPG Funds&quot;), which collectively beneficially own shares of Common Stock.</footnote>
        <footnote id="F5">Ms. Ginsberg disclaims beneficial ownership of all of the securities that are or may be beneficially owned by the TPG Funds or any of their affiliates.  Pursuant to Rule 16a-1(a)(4) under the Securities Exchange Act of 1934, as amended (the &quot;Exchange Act&quot;), this filing shall not be deemed an admission that Ms. Ginsberg is, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any equity securities of the Issuer.</footnote>
    </footnotes>

    <remarks>(6) Matthew Coleman is signing on behalf of Ms. Ginsberg pursuant to the power of attorney dated July 5, 2017, which is attached hereto as an exhibit.</remarks>

    <ownerSignature>
        <signatureName>/s/ Matthew Coleman on behalf of Deborah Ginsberg (6)</signatureName>
        <signatureDate>2017-07-19</signatureDate>
    </ownerSignature>
</ownershipDocument>
