X0306 4 2020-06-15 0 0001604821 Natera, Inc. NTRA 0001711968 Chapman Steven Leonard C/O NATERA, INC., 201 INDUSTRIAL ROAD SUITE 410 SAN CARLOS CA 94070 1 1 0 0 Chief Executive Officer Common Stock 2020-06-15 4 M 0 559 10.41 A 26433 D Common Stock 2020-06-15 4 M 0 521 10.73 A 26954 D Common Stock 2020-06-15 4 M 0 1042 13.01 A 27996 D Common Stock 2020-06-15 4 M 0 1526 9.29 A 29522 D Common Stock 2020-06-15 4 M 0 521 20.27 A 30043 D Common Stock 2020-06-15 4 S 0 3782 40.5908 D 26261 D Common Stock 2020-06-15 4 S 0 675 41.3566 D 25586 D Common Stock 2020-06-16 4 M 0 559 10.41 A 26145 D Common Stock 2020-06-16 4 M 0 521 10.73 A 26666 D Common Stock 2020-06-16 4 M 0 1042 13.01 A 27708 D Common Stock 2020-06-16 4 M 0 1526 9.29 A 29234 D Common Stock 2020-06-16 4 M 0 521 20.27 A 29755 D Common Stock 2020-06-16 4 S 0 4457 45 D 25298 D Stock Option (right to buy) 10.41 2020-06-15 4 M 0 559 0 D 2027-06-08 Common Stock 559 32957 D Stock Option (right to buy) 10.73 2020-06-15 4 M 0 521 0 D 2027-07-13 Common Stock 521 15104 D Stock Option (right to buy) 13.01 2020-06-15 4 M 0 1042 0 D 2029-01-10 Common Stock 1042 73958 D Stock Option (right to buy) 9.29 2020-06-15 4 M 0 1526 0 D 2028-03-08 Common Stock 1526 80892 D Stock Option (right to buy) 20.27 2020-06-15 4 M 0 521 0 D 2029-04-11 Common Stock 521 99479 D Stock Option (right to buy) 10.41 2020-06-16 4 M 0 559 0 D 2027-06-08 Common Stock 559 32398 D Common Stock (right to buy) 10.73 2020-06-16 4 M 0 521 0 D 2017-07-13 Common Stock 521 14583 D Stock Option (right to buy) 13.01 2020-06-16 4 M 0 1042 0 D 2029-01-10 Common Stock 1042 72916 D Stock Option (right to buy) 9.29 2020-06-16 4 M 0 1526 0 D 2028-03-08 Common Stock 1526 79366 D Stock Option (right to buy) 20.27 2020-06-16 4 M 0 521 0 D 2019-04-11 Common Stock 521 98985 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 15, 2020. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $40.00 to $40.99 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $41.315 to $41.47 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The option shares vest over four years. 25% of the option shares vested and became exercisable on March 21, 2018 and the remaining shares vest in 36 equal monthly installments thereafter. The option shares vest over four years. 25% of the option shares vested and became exercisable on March 12, 2018 and the remaining shares vest in 36 equal monthly installments thereafter. The option shares vest over four years. 25% of the option shares vested and became exercisable on January 2, 2020 and the remaining shares vest in 36 equal monthly installments thereafter. The option shares vest over four years. 25% of the option shares vested and became exercisable on March 9, 2019 and the remaining shares vest in 36 equal monthly installments thereafter. The option shares vest over four years. 25% of the option shares vested and became exercisable on March 22, 2020 and the remaining shares vest in 36 equal monthly installments thereafter. /s/ Tami Chen, attorney-in-fact 2020-06-17