X0306 4 2020-03-21 0 0001604821 Natera, Inc. NTRA 0001711968 Chapman Steven Leonard C/O NATERA, INC., 201 INDUSTRIAL ROAD SUITE 410 SAN CARLOS CA 94070 1 1 0 0 Chief Executive Officer Common Stock 2020-03-21 4 M 0 1118 A 2268 D Common Stock 2020-03-22 4 M 0 727 A 2995 D Common Stock 2020-03-22 4 M 0 12500 A 15495 D Common Stock 2020-03-23 4 S 0 580 24.0919 D 14915 D Common Stock 2020-03-23 4 S 0 377 24.0883 D 14538 D Common Stock 2020-03-23 4 S 0 6467 24.0966 D 8071 D Restricted Stock Unit 2020-03-21 4 M 0 1118 0 D Common Stock 1118 4469 D Restricted Stock Unit 2020-03-22 4 M 0 727 0 D Common Stock 727 2183 D Restricted Stock Unit 2020-03-22 4 M 0 12500 0 D Common Stock 12500 37500 D Represents the partial vesting and settlement of Restricted Stock Units ("RSUs"), starting March 21, 2018. Represents the partial vesting and settlement of Restricted Stock Units ("RSUs"), starting March 22, 2020. Each RSU represents a contingent right to receive one share of the common stock of the issuer. The sale of shares was effected in order to satisfy tax liabilities due at the time of vesting. The RSUs vest over four years. 25% of the RSUs vest on March 21, 2018 and the remaining shares vest in 12 equal quarterly installments thereafter. The RSUs vest over four years. 25% of the RSUs vest on March 22, 2020 and the remaining shares vest in 12 equal quarterly installments thereafter. /s/ Tami Chen, attorney-in-fact 2020-03-24