<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001906480</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001711933</issuerCik>
      <issuerName>Akoya Biosciences, Inc.</issuerName>
      <secFileNumber>001-40344</secFileNumber>
      <issuerAddress>
        <com:street1>100 CAMPUS DRIVE</com:street1>
        <com:street2>6TH FLOOR</com:street2>
        <com:city>MARLBOROUGH</com:city>
        <com:stateOrCountry>MA</com:stateOrCountry>
        <com:zipCode>01752</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>855.896.8401</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Moy Marilee</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>ETRADE FINANCIAL CORPORATION</name>
        <address>
          <com:street1>3 EDISON DRIVE</com:street1>
          <com:city>ALPHARETTA</com:city>
          <com:stateOrCountry>GA</com:stateOrCountry>
          <com:zipCode>30005</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>10000</noOfUnitsSold>
      <aggregateMarketValue>71750.00</aggregateMarketValue>
      <noOfUnitsOutstanding>38400000</noOfUnitsOutstanding>
      <approxSaleDate>07/13/2023</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>COMMON</securitiesClassTitle>
      <acquiredDate>07/11/2023</acquiredDate>
      <natureOfAcquisitionTransaction>RESTRICTED STOCK</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>ISSUER</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>10000</amountOfSecuritiesAcquired>
      <paymentDate>07/11/2023</paymentDate>
      <natureOfPayment>COMPENSATION</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>MARILEE MOY</name>
        <address>
          <com:street1>100 CAMPUS DRIVE</com:street1>
          <com:street2>6TH FLOOR</com:street2>
          <com:city>MARLBOROUGH</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>01752</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>RESTRICTED STOCK</securitiesClassTitle>
      <saleDate>07/12/2023</saleDate>
      <amountOfSecuritiesSold>19189</amountOfSecuritiesSold>
      <grossProceeds>135146.12</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>07/13/2023</noticeDate>
      <signature>/s/ Marilee Moy</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
